V. K. Singh

Skeletal Muscle Mitochondrial Dysfunction Mediated by Pseudomonas aeruginosa Quorum Sensing Transcription Factor MvfR: Reversing Effects with Anti-MvfR and Mitochondrial-Targeted Compounds

This study investigates how Pseudomonas aeruginosa's MvfR quorum sensing transcription factor disrupts mitochondrial function in skeletal muscle and shows that inhibiting MvfR or using mitochondrial-targeted compounds can reverse these effects.

Lipidomics of homeoviscous adaptation to low temperatures in Staphylococcus aureus utilizing exogenous straight-chain unsaturated fatty acids over biosynthesized endogenous branched-chain fatty acids

This paper shows that Staphylococcus aureus uses exogenous unsaturated fatty acids to enhance growth at low temperatures through lipid remodeling and carotenoid production.

Insecticidal Effects of Datura Species against Major Agricultural Pests

This study evaluates the insecticidal effects of Datura species against agricultural pests using bioassays with varying concentrations and exposure times.

Defective pgsA contributes to increased membrane fluidity and cell wall thickening in S. aureus with high-level daptomycin resistance

This study shows that mutations in pgsA increase membrane fluidity and cell wall thickness in daptomycin-resistant S. aureus, contributing to resistance.

Inhibition of miR-214 expression by small molecules alleviates head and neck cancer metastasis by targeting ALCAM/TFAP2 signaling.

This study shows that inhibiting miR-214 with EGCG reduces head and neck cancer metastasis by targeting ALCAM/TFAP2 signaling.

Differentially deregulated microRNAs contribute to ultraviolet radiation-induced photocarcinogenesis through immunomodulation: An-analysis of microRNAs expression profiling.

This study identifies differentially expressed miRNAs in UVB-induced skin cancer and shows their role in immunomodulation and photocarcinogenesis.

Tackling Recalcitrant Pseudomonas aeruginosa Infections In Critical Illness via Anti-virulence Monotherapy

This study identifies novel anti-MvfR compounds (NAMs) that reduce intestinal permeability and inflammation in Pseudomonas aeruginosa infections, offering a potential monotherapy for critical illness.

Identification of multi-omics molecular signature of acute radiation injury using nonhuman primate model

This study identifies a 4-analyte serum panel to detect radiation exposure in nonhuman primates using multi-omics data from mass spectrometry.

A multi-omics approach identifies pancreatic cancer cell extracellular vesicles as mediators of the unfolded protein response in normal pancreatic epithelial cells.

Immunometabolic hijacking of immune cells by a Pseudomonas aeruginosa quorum-sensing signal

This study shows how Pseudomonas aeruginosa uses a quorum-sensing signal to reprogram macrophage metabolism, reducing energy and immune responses to promote pathogen persistence.