Allogeneic CAR-invariant Natural Killer T Cells Exert Potent Antitumor Effects Through Host CD8 T cell Cross-Priming
F. Simonetta, J. K. Lohmeyer, T. Hirai, K. Maas-Bauer, M. Alvarez, A. S. Wenokur, J. Baker, A. Aalipour, X. Ji, S. Haile, C. L. Mackall, R. S. Negrin
This study shows allogeneic CAR-iNKT cells effectively combat tumors in mice by directly attacking cancer cells and boosting host CD8 T cell responses, even across major MHC barriers.
bioRxiv · Feb 3, 2021Immunology