M. Alvarez

Interplay of EGFR, JNK and ROS signalling in soma-germline communication in the Drosophila testis

The paper investigates how EGFR, JNK, and ROS signaling interact in Drosophila testis somatic and germline cells to regulate germ cell survival and tissue homeostasis.

PAH DEFICIENT PATHOLOGY IN HUMANIZED c.1066-11G>A PHENYLKETONURIA MICE

This paper generates a partially humanized mouse model of PKU with the c.1066-11G>A PAH variant, showing splicing defects, metabolic imbalances, and neurological phenotypes.

Development of a mouse model for spontaneous oral squamous cell carcinoma in Fanconi anemia

This paper develops a mouse model of spontaneous oral squamous cell carcinoma in Fanconi anemia by combining Fanca gene knockout with conditional Trp53 deletion in oral mucosa.

OncoLoop: A network-based precision cancer medicine framework

OncoLoop predicts and validates drug sensitivity in tumors and their models by leveraging perturbational profiles of oncology drugs, showing success in prostate cancer models and patient cohorts.

Single-cell dissection of obesity-exercise axis in adipose-muscle tissues

This study uses single-cell RNA sequencing to analyze the effects of exercise and diet on adipose and muscle tissues in mice, identifying key cell types and pathways involved in metabolic changes.

Allogeneic CAR-invariant Natural Killer T Cells Exert Potent Antitumor Effects Through Host CD8 T cell Cross-Priming

This study shows allogeneic CAR-iNKT cells effectively combat tumors in mice by directly attacking cancer cells and boosting host CD8 T cell responses, even across major MHC barriers.

Patterns of population genomic diversity in the invasive Japanese knotweed species complex

This study analyzes genetic diversity in invasive Japanese knotweed species using population genomics, finding substantial diversity in the Japanese knotweed cluster despite no genetic structure or local adaptation.

Reduced representation characterization of genetic and epigenetic differentiation to oil pollution in the foundation plant Spartina alterniflora

The paper examines genetic and epigenetic differentiation in Spartina alterniflora populations exposed to oil pollution, finding correlations between exposure and variation in DNA methylation, gene expression, and genotype.