Deubiquitination of phosphoribosyl-ubiquitin conjugates by PDE domain-containing Legionella effectors
M. Wan, A. Sulpizio, A. Akturk, W. H. J. Beck, M. Lanz, V. M. Faca, M. B. Smolka, J. P. Vogel, Y. Mao
This paper identifies DupA and DupB as deubiquitinases that reverse PR-ubiquitination, a novel modification mediated by Legionella effectors, and shows their role in modulating host-pathogen interactions.
bioRxiv · Aug 23, 2019Biochemistry