A. Alexander-Katz

The interplay between adsorption and aggregation of von Willebrand factor chains in shear flows

This study uses Brownian dynamics simulations to investigate how shear flow affects VWF chain adsorption, aggregation, and extension, revealing their interplay in hemostasis.

Probing weak lipid-lipid binding domain interactions with a mechanically transduced immunosorbent assay (METRIS)

This paper introduces METRIS, a new assay to measure weak protein-lipid interactions, and demonstrates its application to study PIP-binding domains with varying affinities.

Multivalent polymers can control phase boundary, dynamics, and organization of liquid-liquid phase separation

This study uses simulations to show how multivalent polymer structure affects liquid-liquid phase separation dynamics and organization in biological systems.

Polymer Stiffness Regulates Multivalent Binding and Liquid-Liquid Phase Separation

This paper shows that flexible polymers bind more strongly to targets and nucleate phase separation at lower energy than rigid polymers, with implications for pathogen inhibition and neurodegenerative diseases.

Computational Insights Into Avidity of Polymeric Multivalent Binders

This study uses Brownian dynamics simulations to show that longer multivalent polymers increase binding avidity to targets but reach a limit at high degrees of polymerization, and improve binding efficiency through inter-target interactions.