TCR signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 NPC subcomplex via phosphorylation of RanGAP1 by PKC-θ
Y. Li, Y. He, Z. Yang, C.-s. Zhao, Y. Gong, Z. Xiao, Y.-y. Li, Y. Chen, D. Feng, A. Altman
This study shows that PKC-θ phosphorylates RanGAP1 to promote its sumoylation and assembly with RanBP2 and Ubc9, facilitating nuclear import of AP-1.
bioRxiv · Mar 10, 2021Cell Biology