Y. Gong

LC3-associated phagocytosis is impaired in monocyte-derived macrophages from systemic sclerosis patients

Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer

This study identifies low tumorous magnesium content as a driver factor of colorectal cancer by showing its impact on gene mutations, EMT activation, and cell migration through DBN1 phosphorylation.

Genomic evidence for supergene control of Darwin's 'complex marriage arrangement' - the tristylous floral polymorphism

The paper identifies two supergenes controlling tristyly in Eichhornia paniculata, with specific gene expression patterns and evolutionary age estimates supporting their role in the polymorphism.

Phylogenomics resolves key relationships in Rumex and uncovers a dynamic history of independently evolving sex chromosomes

This study uses phylogenomic analysis of Rumex species to resolve sex chromosome evolution, finding two independent origins and chromosomal rearrangements without adaptive expansion support.

Nuclear cytoophidia assembly represses transcriptional activity to control skeletal development and homeostasis

This study identifies nuclear cytoophidia as regulators of Impdh2 transcriptional activity, impacting skeletal development and homeostasis through effects on endochondral ossification and osteoclast function.

Phylogeny-metabolism dual-directed single-cell genomics for dissecting and mining ecosystem function

This paper introduces FISH-scRACS-Seq, a method to identify and sequence single cells with specific metabolic functions, revealing a new cyclohexane-degrading enzyme system in marine bacteria.

Presence of NCOR1+/CD4+ T cells in tertiary lymphoid organ predicts favorable prognosis in pancreatic ductal adenocarcinoma

The paper shows that NCOR1+/CD4+ T cells in tertiary lymphoid organs predict better outcomes in pancreatic ductal adenocarcinoma patients.

Phased assembly of neo-sex chromosomes reveals extensive Y degeneration and rapid genome evolution in Rumex hastatulus

The paper studies Y chromosome degeneration in Rumex hastatulus by analyzing phased genome assemblies of old and new sex chromosomes, finding extensive gene loss and transposable element expansion on the Y chromosome.

In vivo selection in non-human primates identifies superior AAV capsids for on-target CSF delivery to spinal cord

The paper identifies superior AAV capsids for targeted spinal cord gene therapy in non-human primates through in vivo selection and evaluates their biodistribution and expression.

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors

This study shows Mecp2 negatively regulates quiescence exit by activating metabolic genes and repressing proliferation genes, with nuclear receptors Rara and Nr1h3 playing a key role.

Does the territorial behaviour of the Amur tiger affect the accuracy of occupancy estimation?

This study develops a modified occupancy model to distinguish true-presence from pseudo-presence in Amur tigers, improving occupancy estimation accuracy by accounting for territorial behavior.

VHL Mutation Drives Human Clear Cell Renal Cell Carcinoma Progression Through PI3K/AKT-Dependent Cholesteryl Ester Accumulation

This study identifies VHL mutation as a driver of CE accumulation in ccRCC through the PI3K/AKT pathway, showing that inhibiting cholesterol esterification suppresses tumor aggressiveness.

Exosome-mediated viral nucleic acid presentation in a crustacean reveals innate immunity evolution from a novel perspective

The paper shows that DNA virus components are packaged into exosomes by infected crustacean cells, which transmit apoptotic signals to suppress viral spread.

Cortical polarity ensures its own asymmetric inheritance in the stomatal lineage to pattern the leaf surface

The paper identifies a mechanism in Arabidopsis thaliana that ensures asymmetric inheritance of a polarity domain during stomatal lineage cell divisions, linking cell polarity to division orientation and fate determination.

Void volume fraction of granular scaffolds

The paper provides simulated granular scaffolds with known void volume fraction (VVF) to study measurement accuracy and reveals VVF may be unreliable as a descriptor.

Mathematical Modeling of Rhesus Cytomegalovirus (RhCMV) Placental Transmission in Seronegative Rhesus Macaques

The paper develops a mathematical model of RhCMV placental transmission in rhesus macaques to study factors affecting congenital CMV infection risk.

Deep Proteome Profiling Enabled Functional Annotation and Data-Independent Quantification of Proline Hydroxylation Targets

The paper develops HypDB, a database of proline hydroxylation sites, and identifies functional roles and biomarkers through proteome analysis.

Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis

The paper shows pre-neoplastic stromal cells promote BRCA1-driven breast cancer by inducing epithelial proliferation and altering differentiation.

On the edge: Evolution of polarity protein BASL and the capacity for stomatal lineage asymmetric divisions

This paper investigates the evolution of the polarity protein BASL in stomatal lineage asymmetric divisions across species, finding it is eudicot-specific and reveals differences in division mechanisms across dicots.

Arabidopsis stomatal polarity protein BASL mediates distinct processes before and after cell division to coordinate cell size and fate asymmetries

The paper investigates the role of BASL in Arabidopsis stomatal lineage asymmetric cell divisions, showing distinct functions before and after division in regulating cell size and fate.

miR-2 contributes to WSSV infection by targeting Caspase 2 in mud crab (Scylla paramamosain)

This study identifies miR-2 as a regulator of Caspase 2 in mud crabs, showing it suppresses WSSV infection through apoptosis induction.

TCR signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 NPC subcomplex via phosphorylation of RanGAP1 by PKC-θ

This study shows that PKC-θ phosphorylates RanGAP1 to promote its sumoylation and assembly with RanBP2 and Ubc9, facilitating nuclear import of AP-1.

Apple ripening is controlled by a NAC transcription factor

This study identifies NAC18.1 as a key gene controlling apple firmness and ripening, showing its functional similarity to the tomato ripening regulator NOR.

Crystal structure of Sulfolobus solfataricus topoisomerase III reveals a novel carboxyl-terminal zinc finger domain essential for decatenation activity

Young and Undamaged rMSA Improves the Longevity of Mice

This study shows that young and undamaged recombinant mouse serum albumin (rMSA) extends the lifespan and healthspan of C57BL/6N mice by 17.6% and 20.3% respectively.

Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals

The paper identifies and characterizes a novel adipocyte population with active Wnt/β-catenin signaling that influences beige fat formation and glucose homeostasis in mice.

An Ultrasensitive Biosensor for Quantifying the Interaction of SARS-CoV-2 and Its Receptor ACE2 in Cells and in vitro

This paper develops an ultrasensitive biosensor to quantify SARS-CoV-2 RBD and ACE2 interactions in cells and in vitro, enabling rapid evaluation of viral mutants and drug candidates.

Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.