Z. Xiao

Restoring O-glycosylation and expression of MUC2 limits progression of colorectal cancer

This study shows that restoring MUC2 O-glycosylation and expression via rosiglitazone inhibits colorectal cancer progression by enhancing intestinal barrier function.

BRD8 guards the pluripotent state by sensing and maintaining histone acetylation

This study shows BRD8 maintains pluripotency by sensing and maintaining histone acetylation, preventing the conversion of primed EpiSCs to naive ESCs.

Testosterone-Induced Metabolic Changes in Seminal Vesicle Epithelial cells Alter Plasma Components to Enhance Sperm Motility

This study identifies testosterone-induced metabolic changes in seminal vesicle epithelial cells that enhance sperm motility through fatty acid synthesis.

Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature

This study develops an in vitro method to generate human intestinal organoids containing multiple cell types, including neurons, endothelial cells, and smooth muscle, which functionally mimic gut physiology.

Generative artificial intelligence GPT-4 accelerates knowledge mining and machine learning for synthetic biology

This paper uses GPT-4 to extract data from synthetic biology papers, creating structured datasets that improve ML predictions for yeast fermentation.

Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors

This study shows that targeting FAP+CAFs in desmoplastic pancreatic tumors reduces stromal barriers, enhances T cell infiltration, and improves response to immunotherapy.

Modulating the epigenetic state promotes the reprogramming of transformed cells to pluripotency in a line-specific manner

This study identifies line-specific barriers to reprogramming transformed cells and shows that MEK inhibition can overcome some of these barriers by modulating the epigenetic state.

TCGADEPMAP -- Mapping Translational Dependencies and Synthetic Lethalities within The Cancer Genome Atlas

TCGADEPMAP maps translational tumor dependencies and synthetic lethality using TCGA data, identifying novel targets like PAPSS1/2 with clinical implications.

The Influence of Leaf Anatomical Traits on Photosynthetic in Coffee Leaves

This study quantifies how anatomical traits of Coffea arabica leaves influence photosynthesis using correlation and path analysis, identifying leaf thickness and stomatal density as key factors.

Diversity analysis of soil microbial population abundance before and after planting JunCao "Oasis No.1" in saline-alkali soil

This study compares microbial diversity in saline-alkali soil before and after planting JunCao 'Oasis No. 1', finding increased diversity and abundance in the experimental group.

Characterization of pyridomycin B reveals the formation of functional groups in antimycobacterial pyridomycin

This study characterizes pyridomycin B, a pyridomycin analogue, revealing that Pyr2 catalyzes ketoreduction and double bond formation in a unique energy-saving manner, contributing to the formation of functional groups in pyridomycin.

Elevated transcriptional pausing of RNA polymerase II underlies acquired resistance to radiotherapy

This study identifies increased RNA polymerase II pausing as a mechanism of acquired radiotherapy resistance in cancer cells and suggests CDK7 inhibitors as a potential therapeutic strategy.

Injectable Nanoparticle-Based Hydrogels Enable the Safe and Effective Deployment of Immunostimulatory CD40 Agonist Antibodies

This paper develops injectable hydrogels to safely deliver CD40 agonist antibodies, reducing toxicity while maintaining anti-cancer efficacy in a melanoma model.

Sub-second multi-channel magnetic control of select neural circuits in behaving flies

This study demonstrates sub-second, multichannel neural stimulation in flies using magnetic nanoparticles and temperature-sensitive ion channels, improving the temporal resolution of magnetogenetics.

TCR signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 NPC subcomplex via phosphorylation of RanGAP1 by PKC-θ

This study shows that PKC-θ phosphorylates RanGAP1 to promote its sumoylation and assembly with RanBP2 and Ubc9, facilitating nuclear import of AP-1.

Single-cell sequencing characterizes intratumoral profile of immune cells in old mice

The paper uses single-cell RNA analysis to compare immune cell profiles in young and old mice, finding higher proportions of effector cells in old mice that may enhance tumor defense.

Nutrient copper signaling promotes protein turnover by allosteric activation of ubiquitin E2D conjugases

This paper shows that copper signaling modulates protein turnover by allosterically activating ubiquitin E2D conjugases, linking copper levels to protein degradation and morphogenesis.

Development of a Triazolobenzodiazepine-Based PET Probe for Subtype-Selective Vasopressin 1A Receptor Imaging

This paper develops a PET probe for subtype-selective V1A receptor imaging in peripheral organs, showing high affinity and selectivity for V1A over other vasopressin receptors.

A human antibody with blocking activity to RBD proteins of multiple SARS-CoV-2 variants including B.1.351 showed potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus macaques

Landscape of glioblastoma niches reveals the prognostic effects of tumor-infiltrating cells

This study identifies prognostic non-tumor cell types in glioblastoma by analyzing gene expression across four cohorts, revealing risk and protective factors associated with immune response clusters.

High-throughput tandem-microwell assay for ammonia repositions FDA-Approved drugs to Helicobacter pylori infection

This study identifies FDA-approved drugs that inhibit urease activity in H. pylori, offering potential new treatments for infections.

Furfural residues as soil amendments for long-term seed corn production: effects on community composition and diversity of rhizosphere microbiota

This study examines how furfural residue amendments affect rhizosphere microbiota diversity and composition in long-term maize monocropping, showing increased beneficial microbes and reduced pathogens.

ORF3a mediated-incomplete autophagy facilitates SARS-CoV-2 replication

This study shows that SARS-CoV-2 ORF3a induces incomplete autophagy by interacting with UVRAG, impairing autophagosome maturation and enhancing viral replication.

Versatile, Multivalent Nanobody Cocktails Efficiently Neutralize SARS-CoV-2

This paper identifies potent SARS-CoV-2 neutralizing nanobodies, develops multivalent cocktails with high neutralization potency, and highlights their therapeutic potential.

A robust and versatile nanobody platform for drug delivery

This paper develops a nanobody platform for drug delivery, showing improved pharmacokinetics and therapeutic efficacy of NbHSA conjugates.

Small molecule FGF23 inhibitors increase serum phosphate and improve skeletal abnormalities in Hyp mice

The Na+/K+ ATPase Regulates Glycolysis and Modifies Immune metabolism in Tumors

This study shows that Na+/K+ ATPase inhibition via digoxin disrupts glycolysis in tumor and healthy cells, alters immune metabolism, and changes tumor microenvironment composition.

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

This study identifies SARS-CoV-2 host targets and perturbed proteins in PBMCs from COVID-19 patients, revealing potential virulence factors involved in cytokine storms and disease pathogenesis.

Quantitative evaluation of a high resolution lipidomics platform

The paper evaluates a high-resolution lipidomics platform that profiles lipids and polar metabolites, showing its ability to detect and quantify over 300 lipids and 300 metabolites with sensitivity and linear range analysis in cultured cells and metformin-treated ovarian cancer cells.

Characterization of aroma-active compounds in delicious apples juices by gas chromatography-mass spectrometry (GC-MS), gas chromatography-olfactometry (GC-O) and odor activity value (OAV)

This study identifies aroma-active compounds in three delicious apple juice cultivars using GC-MS, GC-O, and OAV, finding key contributors to the juice's aroma.