SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
O. A. Romero, A. Villarrubi, J. J. Alburquerque-Bejar, A. Gomez, A. Andrade, D. Trastulli, E. Pros, S. Verdura, L. Farre, J. F. Martin-Tejera, P. Llabata, A. Oaknin, M. Saigi, J. M. Piulats, X. Matias-Guiu, , M. Sanchez-Cespedes
This study identifies KDM6A/UTX and KDM6B/JMJD3 as therapeutic targets in SMARCA4-deficient cancers, showing that their inhibition reduces tumor viability in mouse models.
bioRxiv · Aug 7, 2020Cancer Biology