A. Gomez

Pupation substrate and prepupal handling affect eclosion rate, timing, and adult morphology in black soldier flies (Hermetia illucens; Diptera: Stratiomyidae)

Microphysiological system modeling pericyte-induced temozolomide resistance in glioblastoma

This paper develops a 3D GBM model with pericytes to study TMZ resistance, finding that pericytes increase TMZ resistance in GBM spheroids by upregulating CCL5.

An efficient inducible model for the control of gene expression in renin cells

This paper develops an inducible mouse model to specifically control gene expression in renin cells, demonstrating efficient and targeted deletion of renin in adult mice without developmental effects.

Treponema pallidum periplasmic and membrane proteins are recognized by circulating and skin CD4+ T cells

The paper identifies Tp-specific CD4+ T cell responses in blood and skin of syphilis patients, showing persistence after treatment and highlighting potential vaccine targets.

Sediment source and dose influence the larval performance of the threatened coral Orbicella faveolata

This study examines how sediment source and dose affect the survival and settlement of Orbicella faveolata larvae, finding that port sediments cause more harm than reef sediments, even at lower doses.

Pathogenic Leptospira are widespread in the urban wildlife of southern California

The paper assesses Leptospira prevalence and risk factors in urban wildlife in southern California, finding widespread exposure in multiple species.

Mink on the brink: Comparing survey methods for detecting a Critically Endangered carnivore, the European mink Mustela lutreola

The paper compares survey methods for detecting the Critically Endangered European mink, finding varying detection probabilities and recommending combined methods for effective monitoring.

Sniff Olfactometer (SO) Protocols

This paper describes protocols for using a sniff olfactometer to determine odorant thresholds by measuring odorant recognition probabilities associated with odorant concentrations.

Functional Biomarkers of Ex-vivo Dental Caries Onset

This study identifies five metabolites associated with the onset of dental caries using an ex-vivo model and metabolomics, linking them to specific bacterial taxa.

Inter-subunit coupling enables fast CO2-fixation by reductive carboxylases

This paper investigates the structural and dynamic mechanisms of CO2 fixation by ECRs, revealing inter-subunit coupling that enables fast catalytic activity.

BCN057, a Modulator of GSK3β Induces KRAS G12D Mutant Pancreatic Cancer Cell Death

This paper shows that BCN057, a GSK3β modulator, selectively induces apoptosis in KRAS G12D mutant pancreatic cancer cells while protecting normal intestinal epithelium.

High efficacy of therapeutic equine hyperimmune antibodies against SARS CoV-2 variants of concern

This study demonstrates that therapeutic equine polyclonal antibodies effectively neutralize SARS-CoV-2 variants of concern.

Extraordinarily precise nematode sex ratios: Adaptive responses to vanishingly rare mating options

The paper examines sex ratio strategies in nematodes compared to their host wasps, finding female-biased and precise sex ratios in nematodes due to small mating pools and potential environmental sex determination.

Development and pre-clinical characterization of two therapeutic equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19

This paper develops and pre-clinically evaluates two equine-derived anti-SARS-CoV-2 polyclonal formulations for potential COVID-19 treatment, showing high neutralizing capacity against SARS-CoV-2 infection.

CRIMSON: An Open-Source Software Framework for Cardiovascular Integrated Modelling and Simulation

CRIMSON is an open-source software framework for cardiovascular computational haemodynamics, enabling 3D and reduced-order simulations from medical images to clinical applications.

SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade

This study identifies KDM6A/UTX and KDM6B/JMJD3 as therapeutic targets in SMARCA4-deficient cancers, showing that their inhibition reduces tumor viability in mouse models.

Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.

A novel drug-combination screen in zebrafish identifies epigenetic small molecule candidates for Duchenne muscular dystrophy

The paper identifies two epigenetic small molecules, oxamflatin and salermide, that improve skeletal muscle structure in zebrafish models of Duchenne muscular dystrophy through a drug-combination screen.

Structural adaptation of oxygen tolerance in 4-hydroxybutyrl-CoA dehydratase, a key enzyme of archaeal carbon fixation

The paper investigates how 4HBD, a key enzyme in archaeal carbon fixation, adapted structurally to become oxygen-tolerant, revealing evolutionary changes that enabled aerobic metabolism.

The Object Space Task for mice and rats

This study introduces a new behavioral task for rodents to investigate memory formation, showing that both mice and rats can accumulate information across trials and form long-term abstracted memories.

Supragingival plaque microbiome ecology and functional potential in the context of health and disease

This study examines the supragingival plaque microbiome in children to link microbial diversity and function to caries, identifying key metabolic pathways and novel microbes associated with disease.