X. Matias-Guiu

In vivo intra-uterine delivery of TAT-fused Cre recombinase and CRISPR/Cas9 editing unveil histopathology of Pten/p53-deficient endometrial cancers.

This study shows that simultaneous deletion of Pten and p53 in endometrial epithelial cells leads to epithelial to mesenchymal transition and the formation of uterine carcinosarcomas in vivo.

Immunogenicity of non-canonical HLA-tumor ligands identified through proteogenomics

The paper investigates the immunogenicity of non-canonical HLA-I ligands from tumor cells and finds they are not recognized by autologous T-cells but can be targeted by donor T-cells, suggesting potential as immunotherapy targets.

ARID1A-deficient cells promote endometrial carcinoma progression and dissemination by reprograming tumor microenvironment.

This study shows ARID1A-deficient endometrial tumor cells reprogram the tumor microenvironment, promoting cancer progression and dissemination through chemokine secretion.

LAP1 regulates nuclear plasticity to enable constrained migration

The paper identifies LAP1 as a regulator of nuclear plasticity that enables constrained migration in melanoma cells.

SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade

This study identifies KDM6A/UTX and KDM6B/JMJD3 as therapeutic targets in SMARCA4-deficient cancers, showing that their inhibition reduces tumor viability in mouse models.