J. M. Piulats

Immunogenicity of non-canonical HLA-tumor ligands identified through proteogenomics

The paper investigates the immunogenicity of non-canonical HLA-I ligands from tumor cells and finds they are not recognized by autologous T-cells but can be targeted by donor T-cells, suggesting potential as immunotherapy targets.

Inhibition of Metastatic Uveal Melanoma Cell Proliferation by the Histone Deacetylase 6 Inhibitor, Ricolinostat, is Linked to Altered Microphthalmia-associated Transcription Factor and Phospho-ERK Expression

This study shows that ACY-1215 inhibits metastatic uveal melanoma cell growth in vitro and in vivo by reducing p-ERK and MITF signaling.

A Single-Cell Tumor Immune Atlas for Precision Oncology

The paper creates a single-cell tumor immune atlas using data from 217 patients and 13 cancer types to improve immune cell annotation and spatial mapping for precision oncology.

High Cysteinyl Leukotriene Receptor 1 Expression Correlates with Poor Survival of Uveal Melanoma Patients and Cognate Antagonist Drugs Modulate the Growth, Cancer Secretome, and Metabolism of Uveal Melanoma Cells.

This paper shows high CysLT1 receptor expression in uveal melanoma correlates with poor survival and that CysLT1 antagonists inhibit tumor growth and alter cancer secretome and metabolism.

SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade

This study identifies KDM6A/UTX and KDM6B/JMJD3 as therapeutic targets in SMARCA4-deficient cancers, showing that their inhibition reduces tumor viability in mouse models.

Taxane induces attenuation of the CXCR2/BCL-2 axis and sensitize prostate cancer to platinum-based treatments

This paper identifies that taxane treatment reduces CXCR2 and BCL-2 in mCRPC, making tumors more sensitive to platinum-based therapies.