Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo resistance to artemisinin and chloroquine in Plasmodium berghei.
N. V. Simwela, K. R. Hughes, A. B. Roberts, M. T. Rennie, M. P. Barrett, A. P. Waters
This study experimentally tests mutations in UBP-1 in Plasmodium berghei and shows they confer resistance to artemisinin and chloroquine.
bioRxiv · Dec 12, 2019Microbiology