M. T. Rennie

Mammalian deubiquitinating enzyme inhibitors display in vitro and in vivo activity against malaria parasites and potentiate artemisinin action

This paper shows that mammalian deubiquitinating enzyme inhibitors inhibit malaria parasites in vitro and in vivo, and enhance artemisinin activity, offering a strategy to combat artemisinin resistance.

Experimentally engineered mutations in a ubiquitin hydrolase, UBP-1, modulate in vivo resistance to artemisinin and chloroquine in Plasmodium berghei.

This study experimentally tests mutations in UBP-1 in Plasmodium berghei and shows they confer resistance to artemisinin and chloroquine.