Ebola virus infection of Flt3-dependent, conventional dendritic cells and antigen cross-presentation leads to high levels of T-cell activation
L. R. Niemetz, B. S. Bodmer, C. Olal, B. Escudero-Perez, K. Hoehn, A. Bencsik, M. A. Vickers, E. Rodriguez, L. Oestereich, T. Hoenen, C. Munoz-Fontela
This study shows that Ebola virus infection of Flt3-dependent conventional dendritic cells enhances cross-presentation, leading to increased CD8 T-cell activation in severe EVD.
bioRxiv · May 14, 2024Immunology