Author

O. Kleifeld

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Organism:human· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Rozenberg· 3 shared T. Lavy· 3 shared I. Sahu· 2 shared M. P. Sahoo· 2 shared A. Bonadio· 1 shared A. Brik· 1 shared A. Dhillon· 1 shared A. Dufour· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersBiochemistry

A. Rozenberg

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Author profile →

6 papers

Recent·Most cited

Computational design of Matrix Metalloprotenaise-9 (MMP-9) resistant to auto-cleavage

A. Bonadio, S. Oguche, T. Lavy, O. Kleifeld, J. M. Shifman

The paper designs a stable MMP-9 variant resistant to auto-cleavage while maintaining enzyme activity, suitable for drug development and structural studies.

bioRxiv · Apr 11, 2023Biochemistry

Activity-Guided Proteomic Profiling of Proteasomes Uncovers a Variety of Active (And Inactive) Proteasome species

M. P. Sahoo, T. Lavi, I. Sahu, O. Kleifeld

The paper uses activity-guided proteomic profiling to analyze proteasome composition and activity in yeast, revealing discrepancies between mass spectrometry and activity-based quantification, and identifying factors affecting proteasome function.

bioRxiv · Mar 30, 2023Biochemistry

In-depth characterization of apoptosis N-terminome reveals a link between caspase-3 cleavage and post-translational N-terminal acetylation

R. Hanna, A. Rozenberg, L. Saied, D. Ben-Yosef, T. Lavy, O. Kleifeld

The paper develops a method to study N-terminomes and identifies caspase-3 cleavage sites and their subsequent N-terminal acetylation during apoptosis.

bioRxiv · Sep 19, 2022Biochemistry

Infection cycle and phylogeny of the Polinton-like virus Phaeocystis globosa virus virophage-14T

S. Roitman, A. Rozenberg, T. Lavy, C. P. D. Brussaard, O. Kleifeld, O. Beja

The paper isolates and characterizes a virophage PgVV-14T that co-infects Phaeocystis globosa with PgV-14T, showing it integrates into the host genome and bridges the gap between Polinton-like viruses and virophages.

bioRxiv · Jul 28, 2022Microbiology

An Atlas of Phosphorylation and Proteolytic Processing Events During Excitotoxic Neuronal Death Reveals New Therapeutic Opportunities

S. S. Ameen, A. Dufour, M. I. Hossain, A. Hoque, S. Sturgeon, H. Nandurkar, D. Draxler, R. Medcalf, M. A. Kamaruddin, I. Lucet, M. Leeming, D. Liu, A. Dhillon, J. P. Lim, H. Zhu, , H. C. Cheng

The paper uses proteomic approaches to identify proteins modified during excitotoxic neuronal death and shows that blocking Src kinase protects neurons in a rat model.

bioRxiv · Jun 15, 2020 · PreprintBiochemistry

Signature activities of 20S proteasome include degradation of the ubiquitin-tag with the protein under hypoxia

I. Sahu, S. M. Mali, P. Sulkshane, A. Rozenberg, C. Xu, R. Morag, M. P. Sahoo, S. K. Singh, Z. Ding, Y. Wang, S. Day, Y. Cong, O. Kleifeld, A. Brik, M. H. Glickman

The paper identifies the 20S proteasome's ability to degrade ubiquitin-tagged proteins under hypoxia and shows its role in improving cell survival.

bioRxiv · Dec 20, 2019 · PreprintBiochemistry