Modern clinical Mtb strains leverage the type I IFN pathway for a pro-inflammatory response in the host
D. Shankaran, P. Arumugam, A. Bothra, S. Gandotra, V. K. Rao
The paper identifies how modern Mtb strains use the type I IFN pathway to manipulate host immune responses through enhanced phagosomal acidification and cholesterol metabolism.
bioRxiv · Sep 2, 2019 · PreprintImmunology