Author

D. Shankaran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 1

Frequent Co-Authors

P. Arumugam· 3 shared S. Gandotra· 3 shared V. K. Rao· 2 shared A. Bothra· 1 shared A. Singh· 1 shared M. Chauhan· 1 shared R. Chakraborty· 1 shared S. Dawa· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersImmunology

P. Arumugam

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3 papers

Recent·Most cited

The mitochondrial gene CMPK2 functions as a rheostat for macrophage homeostasis in inflammation

P. Arumugam, M. Chauhan, T. Rajeev, R. Chakraborty, D. Shankaran, S. Ramalingam, S. Gandotra, V. K. Rao

This study shows that altering CMPK2 expression disrupts macrophage mitochondrial function and dysregulates basal inflammation.

bioRxiv · Nov 1, 2021 · PreprintImmunology

The antidepressant sertraline provides a novel host directed therapy module for augmenting TB therapy

D. Shankaran, A. Singh, S. Dawa, P. Arumugam, S. Gandotra, V. Rao

This study shows that sertraline enhances the effectiveness of TB antibiotics in macrophages and mice, suggesting it as a host-directed therapy to improve TB treatment.

bioRxiv · May 26, 2020Immunology

Modern clinical Mtb strains leverage the type I IFN pathway for a pro-inflammatory response in the host

D. Shankaran, P. Arumugam, A. Bothra, S. Gandotra, V. K. Rao

The paper identifies how modern Mtb strains use the type I IFN pathway to manipulate host immune responses through enhanced phagosomal acidification and cholesterol metabolism.

bioRxiv · Sep 2, 2019 · PreprintImmunology