Author

V. K. Rao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Assay:clinical cohort / trial· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

P. Arumugam· 3 shared S. Gandotra· 3 shared D. Shankaran· 2 shared M. J. Lenardo· 2 shared A. Bothra· 1 shared A. F. Carisey· 1 shared A. J. Faruqi· 1 shared A. K. Bhaskar· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersImmunology

P. Arumugam

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The mitochondrial gene CMPK2 functions as a rheostat for macrophage homeostasis in inflammation

P. Arumugam, M. Chauhan, T. Rajeev, R. Chakraborty, D. Shankaran, S. Ramalingam, S. Gandotra, V. K. Rao

This study shows that altering CMPK2 expression disrupts macrophage mitochondrial function and dysregulates basal inflammation.

bioRxiv · Nov 1, 2021 · PreprintImmunology

Inhibition of granuloma triglyceride synthesis imparts control of Mycobacterium tuberculosis through curtailed inflammatory responses

S. Dawa, D. Menon, P. Arumugam, A. K. Bhaskar, M. Mondal, V. K. Rao, S. Gandotra

This study shows that inhibiting triglyceride synthesis in TB granulomas reduces bacterial load and inflammation by targeting DGAT1.

bioRxiv · May 10, 2021Immunology

Human immunodeficiency reveals GIMAP5 as lymphocyte-specific regulator of senescence

A. Y. Park, M. Leney-Greene, M. Lynberg, X. Xu, L. Zheng, Y. Zhang, H. Matthews, B. Chao, A. Morawski, P. Jiang, J. Aluri, E. K. Aydine, A. Kiykim, J. Pascall, I. Barlan, , M. J. Lenardo

This study identifies GIMAP5 as a lymphocyte-specific regulator of senescence, showing that rapamycin can restore naive T cell levels in GIMAP5-deficient patients.

bioRxiv · Feb 22, 2021 · PreprintImmunology

Modern clinical Mtb strains leverage the type I IFN pathway for a pro-inflammatory response in the host

D. Shankaran, P. Arumugam, A. Bothra, S. Gandotra, V. K. Rao

The paper identifies how modern Mtb strains use the type I IFN pathway to manipulate host immune responses through enhanced phagosomal acidification and cholesterol metabolism.

bioRxiv · Sep 2, 2019 · PreprintImmunology

Genetic immunodeficiency and autoimmune disease reveal distinct roles of Hem1 in the WAVE2 and mTORC2 complexes

W. A. Comrie, M. C. Poli, S. A. Cook, M. Similuk, A. Oler, A. J. Faruqi, D. B. Kuhns, S. Yang, A. F. Carisey, B. Fournier, D. E. Anderson, S. Price, W. A. Chahla, A. Vargas-Hernandez, L. R. Forbes, , M. J. Lenardo

Hem1 loss-of-function mutations cause congenital immunodysregulation by disrupting WAVE2 and mTORC2 complexes, leading to immunodeficiency and immune hyperresponsiveness.

bioRxiv · Jul 4, 2019 · PreprintImmunology