S. Gandotra

The mitochondrial gene CMPK2 functions as a rheostat for macrophage homeostasis in inflammation

This study shows that altering CMPK2 expression disrupts macrophage mitochondrial function and dysregulates basal inflammation.

Inhibition of granuloma triglyceride synthesis imparts control of Mycobacterium tuberculosis through curtailed inflammatory responses

This study shows that inhibiting triglyceride synthesis in TB granulomas reduces bacterial load and inflammation by targeting DGAT1.

The antidepressant sertraline provides a novel host directed therapy module for augmenting TB therapy

This study shows that sertraline enhances the effectiveness of TB antibiotics in macrophages and mice, suggesting it as a host-directed therapy to improve TB treatment.

Modern clinical Mtb strains leverage the type I IFN pathway for a pro-inflammatory response in the host

The paper identifies how modern Mtb strains use the type I IFN pathway to manipulate host immune responses through enhanced phagosomal acidification and cholesterol metabolism.

Necrosis triggered by Mycobacterium tuberculosis alters macrophage triglyceride metabolism and inflammatory response in a DGAT1-dependent manner

This study shows that M. tuberculosis-induced necrosis promotes triglyceride storage in macrophages, which enhances inflammation, and that DGAT1 plays a key role in this process.