Author

A. C. Christopher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Srivastava· 2 shared S. Thangavel· 2 shared A. A. Pai· 1 shared A. Bagchi· 1 shared A. Jacob· 1 shared A. K. Dhyani· 1 shared B. Saravanan· 1 shared D. Notani· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Srivastava

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2 papers

Recent·Most cited

Correlating the differences in the receptor binding domain of SARS-CoV-2 spike variants on their interactions with human ACE2 receptor

G. Mahalingam, P. Arjunan, Y. Periasami, A. K. Dhyani, N. Devaraju, V. Rajendiran, A. C. Christopher, R. D. KT, I. Darasingh, S. Thangavel, M. Murugesan, M. Moorthy, A. Srivastava, S. Marepally

The paper evaluates binding interactions of SARS-CoV-2 spike variants with hACE2 using ELISA and cellular models, finding that N501Y in RBD enhances binding efficiency, particularly distinguishing C.1.2 from Delta.

bioRxiv · Sep 30, 2022 · PreprintPharmacology & Toxicology

Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies

V. Venkatesan, A. C. Christopher, P. Babu, M. K. K. Azhagiri, K. Walavalkar, B. Saravanan, S. Srinivasan, K. V. Karuppusamy, A. Jacob, S. Rangaraj, A. Bagchi, A. A. Pai, Y. Nakamura, P. Balasubramanian, R. Pai, , S. Thangavel

This study edits the PRR-βE1 region in HSPCs to suppress HbA and enhance HbF production, showing therapeutic benefits for β-hemoglobinopathies.

bioRxiv · Jul 11, 2022Biochemistry