Author

R. Pai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. A. Pai· 1 shared A. Bagchi· 1 shared A. C. Christopher· 1 shared A. Jacob· 1 shared A. Srivastava· 1 shared B. Saravanan· 1 shared C. Gao· 1 shared D. Hartman· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. A. Pai

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Effect of Nivolumab therapy on Metastatic Lung Cancer in Human Microbiome

R. Kubba, S. Nguyen, J. Borneman, R. Pai, R. J. Evans

This study examines how nivolumab therapy affects the gut microbiome in lung cancer patients, finding a significant reduction in Megasphaera elsdenii levels.

bioRxiv · Jan 3, 2023 · PreprintCancer Biology

Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies

V. Venkatesan, A. C. Christopher, P. Babu, M. K. K. Azhagiri, K. Walavalkar, B. Saravanan, S. Srinivasan, K. V. Karuppusamy, A. Jacob, S. Rangaraj, A. Bagchi, A. A. Pai, Y. Nakamura, P. Balasubramanian, R. Pai, , S. Thangavel

This study edits the PRR-βE1 region in HSPCs to suppress HbA and enhance HbF production, showing therapeutic benefits for β-hemoglobinopathies.

bioRxiv · Jul 11, 2022Biochemistry

Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis

J. Xu, H. Ma, H. Ma, W. Jiang, M. Duan, S. Zhao, C. Gao, E.-R. Hahm, S. Lardo, K. Troy, M. Sun, R. Pai, D. Stolz, S. Singh, R. Brand, , Y. Liu

The paper uses super-resolution imaging to show that chromatin structure decompacts and fragments during early cancer development, even before tumors form, and this change may improve cancer detection and risk assessment.

bioRxiv · Jun 17, 2019Cancer Biology