Author

A. Bagchi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:bulk RNA-seq· 4 Organism:human· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

A. Biswas· 2 shared A. A. Pai· 1 shared A. Bhattacharya· 1 shared A. Bradley· 1 shared A. C. Christopher· 1 shared A. Deshpande· 1 shared A. Halder· 1 shared A. J. Dupuy· 1 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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2 shared papersCancer Biology

A. Biswas

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The Hidden Potential of PDE4 Inhibitor Rolipram: A Multifaceted Examination of its Inhibition of MMP2/9 Reveals Therapeutic Implications

A. Bagchi, A. Roy, A. Halder, A. Biswas

This paper investigates rolipram's inhibition of MMP2/9 beyond its PDE4 activity, showing it affects MMP enzymatic activity and stability through direct protein binding.

bioRxiv · May 16, 2024Cancer Biology

PDE4 inhibitor Rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer

A. Bagchi, A. Bhattacharya, U. Chatterji, A. BISWAS

Rolipram inhibits hedgehog signaling by promoting ubiquitination and degradation of GLI2FL and GLI3FL, reducing GLI1 levels and tumor growth in breast cancer models.

bioRxiv · Mar 3, 2024Cancer Biology

Fast yet force-effective mode of supracellular collective cell migration on aligned fibers due to extracellular force transmission

A. Bagchi, B. Sarker, J. Zhang, M. Foston, A. Pathak

The paper shows that aligned extracellular fibers enable faster, more efficient collective cell migration by enhancing force transmission and front stabilization.

bioRxiv · Oct 22, 2022 · PreprintBiophysics

In vivo functional genomics identifies essentiality of potassium homeostasis in medulloblastoma

J. J. Fan, X. Wang, A. W. Erickson, P. Skowron, X. Wang, X. Chen, G. Shan, S. Bahrampour, Y. Xiong, W. Dong, N. Abeysundara, M. A. Francisco, R. J. Pusong, R. A. Suarez, H. Farooq, , X. Huang

The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.

bioRxiv · Jul 23, 2022Cancer Biology

Editing the core region in HPFH deletions alters fetal and adult globin expression for treatment of β-hemoglobinopathies

V. Venkatesan, A. C. Christopher, P. Babu, M. K. K. Azhagiri, K. Walavalkar, B. Saravanan, S. Srinivasan, K. V. Karuppusamy, A. Jacob, S. Rangaraj, A. Bagchi, A. A. Pai, Y. Nakamura, P. Balasubramanian, R. Pai, , S. Thangavel

This study edits the PRR-βE1 region in HSPCs to suppress HbA and enhance HbF production, showing therapeutic benefits for β-hemoglobinopathies.

bioRxiv · Jul 11, 2022Biochemistry

Enhancement of mitochondrial function fosters B cell immune memory

A. Shukla, A. Tiwari, O. Saulnier, L. D. Hendrikse, B. Hall, R. Rickert, M. Taylor, V. Shukla, A. Bagchi

This study shows that enhancing mitochondrial function with Mdivi-1 improves memory B cell differentiation and vaccine efficacy against influenza and SARS-CoV-2.

bioRxiv · Jun 21, 2022 · PreprintImmunology

A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis In AF10-Rearranged AML

B. Chen, A. Deshpande, K. O. Barbosa, M. Kleppe, X. Lei, N. Yeddula, A. Rosa Campos, R. Wechsler-Reya, A. Bagchi, S. Meshinchi, C. J. Eaves, I. Jeremias, T. Haferlach, D. Frank, Z. Ronai, , A. Deshpande

This study identifies JAK1 as a therapeutic target in AF10-rearranged AML by showing its role in JAK/STAT-mediated inflammatory signaling and oncogenesis.

bioRxiv · Aug 31, 2020Cancer Biology