Author

A. C. Clark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

S. Shrestha· 2 shared J. Titus-McQuillan· 1 shared P. D. Swartz· 1 shared P. T. Hamilton· 1 shared R. D. Grinshpon· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersBiophysics

S. Shrestha

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2 papers

Recent·Most cited

Evolution of the folding landscape of effector caspases

S. Shrestha, A. C. Clark

This study examines the folding landscape of human effector caspases and their common ancestor, showing that the folding mechanism was established early in evolution and retained for over 650 million years.

bioRxiv · Aug 5, 2021Biophysics

Resurrection of ancestral effector caspases identifies novel networks for evolution of substrate specificity

R. D. Grinshpon, S. Shrestha, J. Titus-McQuillan, P. T. Hamilton, P. D. Swartz, A. C. Clark

The paper reconstructs ancestral caspase proteins to identify evolutionary changes in substrate specificity networks.

bioRxiv · Aug 28, 2019Biochemistry