Author

P. T. Hamilton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

B. H. Nelson· 2 shared P. D. Swartz· 2 shared R. D. Grinshpon· 2 shared S. Shrestha· 2 shared A. C. Clark· 1 shared A. De Reynies· 1 shared A. Mezheyeuski· 1 shared A. Miranda· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

B. H. Nelson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer

M. K. Kilgour, S. MacPherson, L. Zacharias, S. Keyes, B. Pauly, B. Allard, J. Smazynski, P. H. Watson, J. Stagg, B. H. Nelson, R. J. DeBerardinis, P. T. Hamilton, J. J. Lum

This study identifies 1-methylnicotinamide (MNA) as an immune regulatory metabolite in high-grade serous ovarian cancer, showing its role in modulating T cell function through non-cell autonomous mechanisms.

bioRxiv · May 5, 2020Immunology

Caspases from Scleractinian Coral Show Unique Regulatory Features

S. Shrestha, J. Tung, R. D. Grinshpon, P. D. Swartz, P. T. Hamilton, B. Dimos, L. Mydlarz, C. Clark

This study identifies and characterizes caspases from disease-sensitive and -resistant corals, revealing unique regulatory features and structural insights into their function.

bioRxiv · Apr 13, 2020Biochemistry

Resurrection of ancestral effector caspases identifies novel networks for evolution of substrate specificity

R. D. Grinshpon, S. Shrestha, J. Titus-McQuillan, P. T. Hamilton, P. D. Swartz, A. C. Clark

The paper reconstructs ancestral caspase proteins to identify evolutionary changes in substrate specificity networks.

bioRxiv · Aug 28, 2019Biochemistry

Cancer stemness, intratumoral heterogeneity, and immune response across cancers

A. Miranda, P. T. Hamilton, A. W. Zhang, E. Becht, A. Mezheyeuski, J. Bruun, P. Micke, A. De Reynies, B. H. Nelson

The paper assesses the relationship between cancer stemness and immune response across 21 solid cancers, finding negative associations between stemness and anticancer immunity.

bioRxiv · Jun 20, 2018Cancer Biology