Enabling MHC-mismatched hematopoietic stem cell transplants and organ graft tolerance without chemotherapy or radiation
B. George, K. S. Kao, A. Chen, A. C. Le, A. Chhabra, C. Burnett, K. M. Loh, J. A. Shizuru, I. Weissman
This study develops six monoclonal antibodies to deplete immune cells in mice, enabling MHC-mismatched HSC transplants without chemotherapy or radiation, leading to immune tolerance.
bioRxiv · Jan 21, 2019 · PreprintImmunology