Author

J. A. Shizuru

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:CITE-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. C. Le· 1 shared A. Chen· 1 shared A. Chhabra· 1 shared B. George· 1 shared C. Burnett· 1 shared C. F. Magnani· 1 shared C. Miskey· 1 shared C. Pellegrino· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. C. Le

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Anti-CD117 CAR T cells incorporating a safety switch eradicate human acute myeloid leukemia and hematopoietic stem cells

C. F. Magnani, R. Myburgh, S. Brunn, M. Chambovey, M. Ponzo, L. Volta, C. Pellegrino, S. Pascolo, C. Miskey, Z. Ivics, J. A. Shizuru, D. Neri, M. G. Manz

This study develops anti-CD117 CAR T cells with a safety switch to target and eliminate acute myeloid leukemia and hematopoietic stem cells in preclinical models.

bioRxiv · Jun 15, 2023Cancer Biology

Enabling MHC-mismatched hematopoietic stem cell transplants and organ graft tolerance without chemotherapy or radiation

B. George, K. S. Kao, A. Chen, A. C. Le, A. Chhabra, C. Burnett, K. M. Loh, J. A. Shizuru, I. Weissman

This study develops six monoclonal antibodies to deplete immune cells in mice, enabling MHC-mismatched HSC transplants without chemotherapy or radiation, leading to immune tolerance.

bioRxiv · Jan 21, 2019 · PreprintImmunology