Author

R. Mangadu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

A. W. Partridge· 2 shared B. Henry· 2 shared P. Gopal· 2 shared S. C. Chang· 2 shared S. Lim· 2 shared S. Ng· 2 shared U. Phan· 2 shared A. C. N. Sim· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

A. W. Partridge

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Author profile →

3 papers

Recent·Most cited

A Light sheet fluorescence microscopy and machine learning-based approach to investigate drug and biomarker distribution in whole organs and tumors.

N. Kumar, P. Hrobar, M. Vagenknecht, J. Soukup, N. Patterson, P. Bloomingdale, T. Freshwater, S. Bardehle, R. Peter, R. Mangadu, C. V. Pastuskovas, C. Y. Chabu, M. T. Cancilla

This paper uses light sheet fluorescence microscopy and machine learning to study drug and biomarker distribution in whole organs and tumors, showing improved segmentation accuracy and subcellular resolution.

bioRxiv · Sep 16, 2023 · PreprintCancer Biology

Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death

S. C. Chang, P. Gopal, S. Lim, X. Wei, R. Mangadu, J. Smith, S. Ng, M. Gindy, U. Phan, B. Henry, A. W. Partridge

This study shows that targeted degradation of PCNA via biodegraders leads to more effective anti-proliferative effects and programmed cell death compared to stoichiometric inhibition.

bioRxiv · Jan 29, 2022Cell Biology

STUB1 is an intracellular checkpoint for interferon gamma sensing

S. Ng, S. Lim, A. C. N. Sim, R. Mangadu, A. Lau, C. Zhang, S. Bollinger Martinez, A. Chandramohan, U.-M. Lim, S. S. W. Ho, S. C. Chang, P. Gopal, L. Z. Hong, A. Schwaid, A. Z. Fernandis, , A. W. Partridge

This study identifies STUB1 as a barrier to interferon gamma sensing, showing it dampens IFNγ response through reduced IFNGR1 surface abundance, but in vivo STUB1 inactivation did not improve ICB outcomes in mouse models.

bioRxiv · Dec 14, 2020Cancer Biology