Author

A. C. Pirkey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

D. J. Klinke· 2 shared W. Deng· 2 shared A. Fernandez· 1 shared A. Razazan· 1 shared D. Norman· 1 shared S. L. McLaughlin· 1 shared S. Rellick· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

D. J. Klinke

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2 papers

Recent·Most cited

Head-to-head comparison of CCN4, DNMT3A, PTPN11, and SPARC as suppressors of anti-tumor immunity

A. C. Pirkey, W. Deng, D. Norman, A. Razazan, D. J. Klinke

This study identifies CCN4 as a secreted factor mediating immunosuppression in melanoma and shows its knockout improves immune-mediated tumor control in immunocompetent mice.

bioRxiv · Apr 1, 2022Cancer Biology

Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma

A. Fernandez, W. Deng, S. L. McLaughlin, A. C. Pirkey, S. Rellick, D. J. Klinke

This study shows that CCN4 promotes immunosuppression in melanoma by reducing CD8+ T cells and increasing MDSCs, and that its removal enhances immune checkpoint therapy effectiveness.

bioRxiv · Feb 23, 2021Cancer Biology