D. J. Klinke

Head-to-head comparison of CCN4, DNMT3A, PTPN11, and SPARC as suppressors of anti-tumor immunity

This study identifies CCN4 as a secreted factor mediating immunosuppression in melanoma and shows its knockout improves immune-mediated tumor control in immunocompetent mice.

Cell Communication Network factor 4 promotes tumor-induced immunosuppression in melanoma

This study shows that CCN4 promotes immunosuppression in melanoma by reducing CD8+ T cells and increasing MDSCs, and that its removal enhances immune checkpoint therapy effectiveness.

Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival

This study shows IL-12 enhances B16F0 melanoma cell survival through non-canonical PI3K-AKT signaling, distinct from its canonical role in immune cells.

An unsupervised feature extraction and selection strategy for identifying epithelial-mesenchymal transition state metrics in breast cancer and melanoma

The paper develops an unsupervised gene signature to identify epithelial-mesenchymal transition state metrics in breast cancer and melanoma using principal component analysis and resampling.

Cell Communication Network factor 4 (CCN4/WISP1) shifts melanoma cells from a fragile proliferative state to a resilient metastatic state

This study shows CCN4 promotes melanoma metastasis by shifting cells from a proliferative to a resilient state, with implications for therapy and biomarker development.

WNT1 Inducible Signaling Pathway Protein 1 (WISP1) Stimulates Melanoma Cell Invasion and Metastasis by Promoting Epithelial - Mesenchymal Transition (EMT)

This study shows WISP1 promotes melanoma invasion and metastasis by inducing EMT through Akt and MAP kinase pathways.

Quantifying Spontaneous Metastasis In A Syngeneic Mouse Melanoma Model Using Real Time PCR

This paper develops a qPCR method to quantify spontaneous metastasis in a syngeneic mouse melanoma model, showing higher sensitivity than bioluminescence imaging.