Conditional Antibody Expression to Avoid Central B Cell Deletion in a Humanized HIV-1 Vaccine Mouse Models
M. Tian, K. McGovern, H.-L. Cheng, P. Waddicor, L. Rieble, M. T. Kimble, M. Dao, Y. Chen, E. Cantor, N. Manfredonia, R. Judson, A. Chapdelaine-Williams, D. W. Cain, B. F. Haynes, F. W. Alt
This paper develops a conditional expression strategy to enable mature B cell expression of bnAb precursors in transgenic mice, overcoming developmental blocks caused by bnAb properties.
bioRxiv · Jan 3, 2020Immunology