M. Tian

Spatial integration of sensory input and motor output in Pseudomonas aeruginosa chemotaxis through colocalized distribution

This study shows that chemoreceptor clusters and flagellar motors colocalize at the same pole in Pseudomonas aeruginosa, controlled by FlhF, and that CheY overexpression increases c-di-GMP, causing cell aggregation.

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.

Integrating leaf gas exchange and chlorophyll fluorescence to reveal the long-term regulation of photosynthesis in situ

The paper introduces a method to measure leaf gas exchange and chlorophyll fluorescence simultaneously over long periods in situ, revealing diurnal and seasonal patterns in photosynthesis regulation.

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1alpha axis in melanoma

This study shows TIPE promotes glycolysis and stemness in melanoma by interacting with PKM2 and activating HIF-1α through phosphorylation.

ESCRT pathway-dependent MVBs contribute to the morphogenesis of the fungus Arthrobotrys oligospora

This study shows that the ESCRT pathway and MVBs are essential for trap formation in the nematode-trapping fungus Arthrobotrys oligospora in response to ammonia.

Mutation-Guided Vaccine Design: A Strategy for Developing Boosting Immunogens for HIV Broadly Neutralizing Antibody Induction

The paper demonstrates a mutation-guided vaccine strategy that induces HIV broadly neutralizing antibodies in mice by selecting for rare B cell lineage mutations.

Humanized V(D)J-rearranging and TdT-expressing Mouse Vaccine Models with Physiological HIV-1 Broadly Neutralizing Antibody Precursors

This paper introduces new mouse models expressing human HIV-1 broadly neutralizing antibody (bnAb) precursors with more physiological levels and diversity, enhancing vaccine research for bnAb elicitation.

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

The paper describes a humanized antibody, SP1-77, that neutralizes all SARS-CoV-2 variants by blocking membrane fusion instead of ACE2 receptor binding.

Development of a ferritin-based nanoparticle vaccine against the SARS-CoV-2 Omicron variant

This paper develops a ferritin-based nanoparticle vaccine targeting the SARS-CoV-2 Omicron variant, showing enhanced immunogenicity compared to a non-nanoparticle version.

Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules

The paper shows that chromogranin proteins undergo liquid-liquid phase separation at the TGN to recruit and sort proinsulin and other cargo molecules into secretory granules, independent of specific sequence elements.

Engineered human brown adipocyte microtissues improved glucose and insulin homeostasis in high fat diet-induced obese and diabetic mice

This study develops 3D human brown adipose microtissues that improve glucose and insulin homeostasis in obese and diabetic mice.

Dual transcriptional analysis of Peronospora belbahrii and Ocimum basilicum in susceptible interactions

The paper analyzes transcriptomes of Peronospora belbahrii and Ocimum basilicum during infection, identifying differentially expressed genes and pathways involved in defense and pathogen growth.

Population Differentiation of Rhodobacteraceae Along Coral Compartments

This study examines how different coral compartments shape microbial evolution by analyzing genome sequences of Rhodobacteraceae in mucus and skeleton, identifying genetic adaptations to compartment-specific environments.

Infection and chronic disease activate a brain-muscle signaling axis that regulates muscle performance

This study identifies a brain-muscle signaling axis activated by infections and chronic diseases that reduces muscle performance through cytokine-dependent mechanisms.

An In Vivo Method for Diversifying the Functions of Therapeutic Antibodies

This paper develops a method to diversify therapeutic antibodies by mimicking natural B cell processes in mice, resulting in new antibodies with altered functions.

Transcriptome analysis of potato leaves in response to infection with the necrotrophic pathogen Alternaria solani

This study analyzes the transcriptome of potato leaves infected with Alternaria solani to identify gene expression changes and hormone responses associated with disease resistance.

H2O2/ABA signal pathway participates in the regulation of stomata opening of cucumber leaves under salt stress by putrescine

This study shows that exogenous putrescine alleviates salt stress-induced photosynthesis inhibition in cucumber by regulating stomatal aperture through the H2O2/ABA signaling pathway.

Paxillin Promotes ATP-induced Activation of P2X7 Receptor and NLRP3 Inflammasome

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.

Conditional Antibody Expression to Avoid Central B Cell Deletion in a Humanized HIV-1 Vaccine Mouse Models

This paper develops a conditional expression strategy to enable mature B cell expression of bnAb precursors in transgenic mice, overcoming developmental blocks caused by bnAb properties.

Structure-guided molecular grafting of a complex broadly neutralizing viral epitope

This paper describes the engineering of immunogens that present a conserved viral epitope using avian influenza HAs, showing they are immunogenic and can enrich for RBS-directed antibodies.

An evaluation model for aboveground biomass Based on Hyperspectral Data from field and TM8 in Khorchin grassland, China

This study evaluates a hyperspectral model for estimating aboveground biomass in Khorchin grassland using field and TM8 data, finding an exponential relationship with R2 = 0.636.

STING recruits NLRP3 to the ER and deubiquitinates NLRP3 to activate the inflammasome

This study shows STING activates the NLRP3 inflammasome by recruiting NLRP3 to the ER and deubiquitinating it, enhancing IL-1β secretion and inflammatory responses.