Targeting Pregnane X Receptor with a Potent Agonist-Based PROTAC to Delay Colon Cancer Relapse
L. Bansard, G. Laconde, V. Delfosse, T. Huet, M. Ayeul, E. Rigal, Q. Donati, S. Gerbal-Chaloin, M. Daujat-Chavanieu, B. Legrand, A. Chavanieu, J. Pannequin, W. Bourguet, M. Amblard, J.-M. Pascussi
This study designs and tests a PXR agonist-based PROTAC (JMV7048) that degrades PXR in cancer cells, reducing chemoresistance and delaying colon cancer relapse.
bioRxiv · Jun 18, 2024 · PreprintCancer Biology