Author

J. Pannequin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

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Research Focus:cancer & tumor microenvironment· 6 Approach:experimental assay· 6 Organism:human· 5 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Bastide· 2 shared A. Choquet· 2 shared A. David· 2 shared F. Macari· 2 shared H. Guillorit· 2 shared S. Relier· 2 shared A. AMALRIC· 1 shared A. ATTINA· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersCancer Biology

A. Bastide

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6 papers

Recent·Most cited

The aminoglycoside streptomycin triggers ferroptosis in tumor initiating cells

H. Guillorit, S. Relier, B. Zagiel, A. Di Giorgio, C. Cazevieille, L. Bansard, C. Bouclier, X. Mialhe, M. Brisset, S. Hideg, A. Choquet, C. Planque, A. Bastide, J. Pannequin, M. Duca, , A. David

This study shows that streptomycin induces ferroptosis in tumor initiating cells by altering mitochondrial morphology and ROS production, with its aldehyde group critical for this effect.

bioRxiv · Oct 31, 2022 · PreprintCancer Biology

Regulation of Src tumor activity by its N-terminal intrinsically disordered region

E. APONTE, M. Lafitte, A. Sirvent, V. Simon, M. barbery, E. Fourgous, M. Maffei, F. Armand, R. Hamelin, J. Pannequin, P. P. Fort, M. Pons, s. roche

This study identifies the ULBR in Src as essential for its oncogenic activity by modulating membrane substrate phosphorylation.

bioRxiv · May 10, 2021Cancer Biology

FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell

S. RELIER, J. RIPOLL, H. GUILLORIT, A. AMALRIC, F. BOISSIERE, J. VIALARET, A. ATTINA, F. DEBART, A. CHOQUET, F. MACARI, E. SAMALIN, J.-J. VASSEUR, J. PANNEQUIN, E. CRAPEZ, C. HIRTZ, , A. DAVID

This study shows FTO-mediated m6Am demethylation reduces CSC properties in colorectal cancer by affecting translation efficiency, not transcriptome remodeling.

Nature Communications · Mar 19, 2021Peer-reviewedCancer Biology

GNS561, a new autophagy inhibitor active against cancer stem cells in hepatocellular carcinoma and hepatic metastasis from colorectal cancer

S. Brun, J.-M. Pascussi, E. P. Gifu, E. Bestion, Z. Macek-Jilkova, G. Wang, F. Bassissi, S. Mezouar, J. Courcamberck, P. Merle, T. Decaens, J. Pannequin, P. Halfon, C. Caron de Fromentel

This study shows that GNS561, an autophagy inhibitor, effectively targets both cancer stem cells and bulk tumor cells in hepatocellular carcinoma and colorectal cancer metastasis.

bioRxiv · Dec 21, 2020Cancer Biology

Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

G. Jacquemin, A. Wurmser, M. Huyghe, W. Sun, Z. Homayed, C. Merle, F. Qasrawi, M. Perkins, S. Richon, F. Dingli, G. Arras, D. Loew, D. Vignjevic, J. Pannequin, S. Fre

This study identifies THBS1-YAP signaling as a paracrine mechanism that reprograms healthy intestinal epithelial cells to support tumor growth.

bioRxiv · Dec 16, 2020Cancer Biology

Alteration of ribosome function upon 5-fluorouracil treatment favours cancer cell drug-tolerance

G. Therizols, Z. Bash-Imam, B. Panthu, C. Machon, A. Vincent, S. Nait Slimane, M. Garcia, F. Laforets, V. Marcel, J. Boubaker-Vitre, G. Souahlia, M.-A. Albaret, H. C. Mertani, M. Prudhomme, M. Bertrand, , J.-J. Diaz

This study shows that 5-FU treatment creates fluorinated ribosomes that selectively translate survival genes, promoting drug tolerance in cancer cells.

bioRxiv · Jun 4, 2020 · PreprintCancer Biology