W. Bourguet

2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors

This study shows that 2,4-DTBP induces adipogenesis in human MSCs by activating RXR, suggesting it as an obesogen and endocrine disruptor.

Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex

The paper presents a cryo-EM structure of the AHR complex bound to a ligand, revealing structural details of its activation mechanism and ligand-binding specificity.

Functional analyses of phosphatidylserine/PI(4)P exchangers with diverse lipid species and membrane contexts set unanticipated rules on lipid transfer

This study investigates how lipid transfer proteins exchange phosphatidylserine and phosphatidylinositol 4-phosphate, revealing that their transfer speed inversely depends on ligand affinity and that they cannot use PI(4,5)P2 for exchange.

Structural insights into the cooperative interaction of the intrinsically disordered co-activator TIF2 with retinoic acid receptor heterodimer (RXR/RAR)

The paper determines the structural features of TIF2NRID and its cooperative binding to RXR/RAR, revealing partially structured regions and the role of flanking sequences.

Interplay of protein disorder in retinoic acid receptor heterodimer and its corepressor regulates gene expression

This study shows that the structural dynamics of the H12 helix in RXR/RAR heterodimers and the intrinsic disorder of N-CoR regulate gene expression through conformational changes and corepressor complex formation.