A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3β as a new target
H. Davaapil, M. McNamara, A. Granata, R. G. C. Macrae, M. Hirano, M. Fitzek, J. A. Aragon-Martin, A. Child, D. M. Smith, S. Sinha
The paper screens small molecules in MFS patient-derived VSMCs to identify GSK3β as a novel therapeutic target for aortic disease.
bioRxiv · Apr 11, 2022Cell Biology