M. Hirano

The energetic stress cytokine GDF15 is elevated in the context of chronic and acute psychosocial stress

This paper shows that GDF15 levels rise with psychosocial stress, depression, anxiety, and biological aging, and that saliva GDF15 has a distinct diurnal pattern and responds rapidly to acute stress.

Comparison of monomeric variants of StayGold

This study compares three monomeric variants of StayGold to evaluate their photostability, brightness, and dispersibility, highlighting tradeoffs in fluorescent protein technology.

StayGold Photostability under Different Illumination Modes

This study compares the photostability of StayGold with three other FPs under different illumination modes in microscopy, finding that StayGold maintains superior photostability in multi-beam LSCM but shows variable performance in single-beam LSCM.

Accelerated physiology and increased energy expenditure in animals and humans with mitochondrial defects: A meta-analysis

This study meta-analyzes energy expenditure in mitochondrial defect models, finding elevated energy costs in 51% of animal studies and similar trends in humans, suggesting hypermetabolism.

Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging

The paper shows chronic glucocorticoid exposure increases cellular energy expenditure and accelerates aging in human fibroblasts.

A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3β as a new target

The paper screens small molecules in MFS patient-derived VSMCs to identify GSK3β as a novel therapeutic target for aortic disease.

Leukocyte cytokine responses in adult patients with mitochondrial DNA defects

This study examines cytokine responses and glucocorticoid sensitivity in leukocytes from patients with mitochondrial DNA defects, finding reduced IL-6 and IL-1β responses to LPS in those with mtDNA deletions.

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

The paper shows that OxPhos dysfunction leads to hypermetabolism and reduced lifespan in cells and mitochondrial disease patients.

A Multi-Omics and Bioenergetics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations

The paper presents a longitudinal multi-omics dataset of human fibroblasts with mitochondrial perturbations to study aging mechanisms and bioenergetics.

A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes

The paper analyzes gene expression changes in hiPSC-derived cardiomyocytes using single-cell RNA-seq, identifying key genes that mark differentiation stages and sources of variation across protocols and cell lines.

Cell states beyond transcriptomics: integrating structural organization and gene expression in hiPSC-derived cardiomyocytes

The paper integrates gene expression and sarcomere organization in hiPSC-derived cardiomyocytes to predict subcellular states and reveal correlations between transcript abundance and structural patterns.

Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses

The paper identifies TOP3B as essential for replication of positive-sense RNA viruses, including SARS-CoV-2, suggesting it as a potential antiviral target.

Microbial single-cell RNA sequencing by split-pool barcoding

The paper introduces microSPLiT, a scRNA-seq method for bacteria, and applies it to Bacillus subtilis to reveal transcriptional states and novel gene expression patterns.

Human Aging DNA Methylation Signatures are Conserved but Accelerated in Cultured Fibroblasts