SARS-CoV-2 shifts transcription of host gene to increase Spike acylation and boost infectivity
F. S. Mesquita, L. Abrami, L. Bracq, N. Panyain, V. Mercier, B. Kunz, A. Chuat, J. Carlevaro-Fita, D. Trono, F. G. van der Goot
This study shows SARS-CoV-2 infection alters zddhc20 transcription, producing a longer ZDHHC20 protein that enhances Spike acylation and viral infectivity.
bioRxiv · Apr 15, 2023 · PreprintCell Biology