Modeling Immunoglobulin light chain amyloidosis in Caenorhabditis elegans
M. Romeo, M. M. Barzago, A. Corbelli, S. Maglioni, N. Ventura, C. Natale, A. Conz, M. Salmona, G. Palladini, M. Nuvolone, F. Fiordaliso, G. Merlini, L. Diomede
This study develops a C. elegans model expressing a human amyloidogenic light chain to study cardiac tropism in AL amyloidosis, finding pharyngeal impairment and oxidative stress similar to human cardiac disease.
bioRxiv · Jul 5, 2024 · PreprintPathology