Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase
H. T. Pacl, J. L. Tipper, R. R. Sevalkar, A. Crouse, C. Crowder, UAB Precision Medicine Institute, S. Ahmad, A. Ahmad, G. D. Holder, C. J. Kuhlman, K. C. Chinta, S. Nadeem, T. J. Green, C. M. Petit, A. J. Steyn, , K. S. Harrod
This paper identifies water-soluble tocopherol derivatives as potent inhibitors of SARS-CoV-2 RNA-dependent RNA polymerase, showing synergy with remdesivir.
bioRxiv · Jul 13, 2021 · PreprintMicrobiology