Author

R. R. Sevalkar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

A. J. Steyn· 3 shared J. N. Glasgow· 3 shared H. T. Pacl· 2 shared J. R. Lancaster· 2 shared K. C. Chinta· 2 shared S. Nadeem· 2 shared V. P. Reddy· 2 shared A. Agarwal· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersMicrobiology

A. J. Steyn

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

H. T. Pacl, K. C. Chinta, V. P. Reddy, S. Nadeem, R. R. Sevalkar, K. Nargan, K. Lumamba, T. Naidoo, J. N. Glasgow, A. Agarwal, A. J. C. Steyn

This study shows that NAD(H) homeostasis in glycolytic myeloid cells is critical for host protection against tuberculosis, with nicotinamide reducing Mtb lung burden.

bioRxiv · Sep 11, 2022 · PreprintMicrobiology

Convergence of two global regulators to coordinate expression of essential virulence determinants of Mycobacterium tuberculosis

H. Khan, P. Paul, R. R. Sevalkar, S. Kachhap, B. Singh, D. Sarkar

The paper identifies a regulatory mechanism where CRP and PhoP co-activate virulence genes in M. tuberculosis through protein-protein interactions and promoter recruitment.

bioRxiv · Jun 30, 2022Microbiology

Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase

H. T. Pacl, J. L. Tipper, R. R. Sevalkar, A. Crouse, C. Crowder, UAB Precision Medicine Institute, S. Ahmad, A. Ahmad, G. D. Holder, C. J. Kuhlman, K. C. Chinta, S. Nadeem, T. J. Green, C. M. Petit, A. J. Steyn, , K. S. Harrod

This paper identifies water-soluble tocopherol derivatives as potent inhibitors of SARS-CoV-2 RNA-dependent RNA polymerase, showing synergy with remdesivir.

bioRxiv · Jul 13, 2021 · PreprintMicrobiology

Mycobacterium tuberculosis DosS binds H2S through its Fe3+ heme iron to regulate the Dos dormancy regulon

R. R. Sevalkar, J. N. Glasgow, M. Pettinati, M. A. Martin, V. P. Reddy, S. Basu, E. Alipour, D. B. Kim-Shapiro, D. A. Estrin, J. R. Lancaster, A. J. Steyn

This study shows Mycobacterium tuberculosis uses its DosS sensor kinase to detect H2S via Fe3+ heme binding, activating the dormancy regulon.

bioRxiv · Jun 21, 2021 · PreprintBiochemistry

Mycobacterium tuberculosis H2S functions as a sink to modulate central metabolism, bioenergetics, and drug susceptibility

T. T. R. Kunota, M. A. Rahman, B. E. Truebody, J. S. Mackenzie, V. Saini, D. A. Lamprecht, J. H. Adamson, R. R. Sevalkar, J. R. Lancaster, M. Berney, J. N. Glasgow, A. J. Steyn

This study identifies H2S as an endogenous molecule in M. tuberculosis that modulates metabolism, bioenergetics, and drug susceptibility.

bioRxiv · Jun 2, 2021Microbiology