S. Ahmad

Co-circulation of distinct high pathogenicity avian influenza virus (HPAIV) subtypes in a mass mortality event in wild seabirds and co-location with dead seals

The paper reports the co-circulation of H5N1 and H5N5 HPAIV subtypes in a mass mortality event involving seabirds and seals in Great Britain, with the first recorded instance of two subtypes co-occurring in the same avian population and the first H5N5 detection in mammals in GB.

Small Extracellular Vesicle Signaling and Mitochondrial Transfer Reprograms T Helper Cell Function in Human Asthma

This study shows that mitochondrial-containing sEVs from MDRCs activate and polarize Th17 and Th2 cells in asthma, contributing to airway inflammation.

A resource to enable chemical biology and drug discovery of WDR Proteins

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

Heterologous expression and characterization of mutant cellulase from indigenous strain of Aspergillus niger

This paper reports the mutagenesis and heterologous expression of a cellulase from Aspergillus niger, showing enhanced enzymatic activity and stability.

Dose, temperature and formulation shape Metarhizium anisopliae virulence against the oriental fruit fly: lessons for improving on-target control strategies

This study evaluates how dose, temperature, and formulation affect the virulence of Metarhizium anisopliae against the oriental fruit fly, providing insights for improving biological control strategies.

Video Diffusion models for the apoptosis forcasting

This paper introduces a video diffusion model for early apoptosis prediction by considering cell-cell interactions and spatial-temporal dynamics, achieving high accuracy and low error rates.

MicroRNA-541-3p alters lipoproteins to reduce atherosclerosis by degrading Znf101 and Casz1 transcription factors

This study identifies miR-541-3p as a regulator that reduces atherosclerosis by decreasing apoB and increasing apoA1 through degradation of Znf101 and Casz1 transcription factors.

Immunotherapy for ovarian cancer is improved by tumor targeted delivery of a neoantigen surrogate

This study shows that delivering a neoantigen surrogate via Listeria monocytogenes combined with gemcitabine and anti-PD1 improves ovarian cancer treatment in mice.

Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

This study quantifies how clonal stochasticity in NK cell responses to MCMV arises from proliferation and death dynamics of mature NK subsets.

Matrix-associated extracellular vesicles modulate smooth muscle cell adhesion and directionality by presenting collagen VI.

This paper shows that fibronectin stimulates vascular smooth muscle cells to secrete collagen VI-rich extracellular vesicles that modulate cell adhesion and directionality by forming focal adhesions in the extracellular matrix.

Candida khanbhai sp. nov., a new clinically relevant yeast within the Candida haemulonii species complex

The paper describes a new yeast species, Candida khanbhai, within the Candida haemulonii complex and corrects the invalid descriptions of several related species.

A study on packed cell volume for deducing hemoglobin: Cholistani camels in perspective

This study evaluates the relationship between hemoglobin and packed cell volume in camels and proposes a new formula for estimating hemoglobin from PCV.

Drought and flooding resistances of maize germplasm are compared and evaluated using a multivariate analysis method

The paper evaluates drought and flooding resistance in maize germplasm using multivariate analysis and identifies key physiological indicators for resistance.

Immunological imprinting of humoral immunity to SARS-CoV-2 in children

This study examines immune responses to Omicron variants in children, finding weak initial antibody responses that improve with reinfection or vaccination, while cellular immunity remains robust across all groups.

Going Beyond the Point Neuron: Active Dendrites and Sparse Representations for Continual Learning

This paper explores using dendritic properties in artificial neural networks to improve continual learning and reduce catastrophic forgetting.

In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris

The paper identifies a mutation in the ERG6 gene as the first mechanism of amphotericin B resistance in Candida auris, observed during in vivo treatment.

Structure of a bacterial Rhs effector exported by the type VI secretion system

The paper presents the structure of the RhsA effector and its cognate VgrG1 spike protein from Pseudomonas protegens, revealing their assembly and potential mechanism of action via the T6SS.

Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase

This paper identifies water-soluble tocopherol derivatives as potent inhibitors of SARS-CoV-2 RNA-dependent RNA polymerase, showing synergy with remdesivir.

Substrate access mechanism in a novel membrane-bound phospholipase A of Pseudomonas aeruginosa concordant with specificity and regioselectivity

This study identifies the substrate access pathway and active site tunnel of PlaF, revealing how its structure influences specificity and regioselectivity in phospholipase A1 activity.

Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA

This study shows stress granules regulate immune responses to dsRNA by preventing excessive inflammation and viral replication.

Interaction of the Causal Agent of Apricot bud gall Acalitus phloeocoptes (Nalepa) with Apricot: Implications in Infested Tissues

This study investigates the interaction between the apricot bud gall mite and its host, revealing hormonal changes that drive gall development and providing insights for pest management.

Genome sequencing and functional genes comparison between Sphingopyxis USTB-05 and Sphingomonas morindae NBD5

This study sequenced and compared the genomes of two Sphingomonadaceae strains, revealing shared lutein synthesis genes and unique genes for hepatotoxin degradation in Sphingopyxis USTB-05.

Voltage-Gated Potassium Channel Kv1.3 as a Therapeutic Target for Pancreatic Ductal Adenocarcinoma

This study shows Kv1.3 is highly expressed in human PDAC and novel Kv1.3 inhibitors combined with chemotherapy significantly reduce tumor growth in mouse models.

Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection

This study shows that SARS-CoV-2-specific T-cell immunity remains robust six months after infection, with response magnitude linked to initial infection severity.

Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones

The paper identifies a conserved motif in TMD-containing effectors and reveals how Eag chaperones stabilize these domains for T6SS-mediated secretion.

Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

The paper reveals conserved interaction rules between RNA helicases and TRIM E3 ligases in vertebrate innate immunity using cryo-EM and biochemistry.

Ubiquitin-dependent and -independent roles of E3 ligase RIPLET in innate immunity

RIPLET functions as a molecular glue to assemble signaling scaffolds for the antiviral innate immune receptor RIG-I.