Author

H. T. Pacl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

K. C. Chinta· 2 shared R. R. Sevalkar· 2 shared S. Nadeem· 2 shared A. Agarwal· 1 shared A. Ahmad· 1 shared A. Crouse· 1 shared A. J. C. Steyn· 1 shared A. J. Steyn· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMicrobiology

K. C. Chinta

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis

H. T. Pacl, K. C. Chinta, V. P. Reddy, S. Nadeem, R. R. Sevalkar, K. Nargan, K. Lumamba, T. Naidoo, J. N. Glasgow, A. Agarwal, A. J. C. Steyn

This study shows that NAD(H) homeostasis in glycolytic myeloid cells is critical for host protection against tuberculosis, with nicotinamide reducing Mtb lung burden.

bioRxiv · Sep 11, 2022 · PreprintMicrobiology

Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase

H. T. Pacl, J. L. Tipper, R. R. Sevalkar, A. Crouse, C. Crowder, UAB Precision Medicine Institute, S. Ahmad, A. Ahmad, G. D. Holder, C. J. Kuhlman, K. C. Chinta, S. Nadeem, T. J. Green, C. M. Petit, A. J. Steyn, , K. S. Harrod

This paper identifies water-soluble tocopherol derivatives as potent inhibitors of SARS-CoV-2 RNA-dependent RNA polymerase, showing synergy with remdesivir.

bioRxiv · Jul 13, 2021 · PreprintMicrobiology