Coincidence detection of mitogenic signals via cytosolic pH regulates Cyclin D1 expression
L. M. Koch, E. Birkeland, S. Battaglioni, X. Helle, M. Meerang, S. Hiltbrunner, A. Ibanez, M. Peter, A. Curioni, I. Opitz, R. Dechant
The paper shows that elevated cytosolic pH regulates Cyclin D1 expression through E2F-dependent transcription and CREB1-p300/CBP interaction, linking pH changes to cell proliferation and cancer progression.
bioRxiv · Jul 15, 2020Cell Biology