Author

L. M. Koch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Peter· 2 shared A. Arm· 1 shared A. Curioni· 1 shared A. Ibanez· 1 shared A. Vukolic· 1 shared C. Cortijo· 1 shared C. Eichmann· 1 shared C. Hirt· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

M. Peter

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A conserved mechanism regulates reversible amyloids via pH-sensing regions

G. Cereghetti, V. M. Kissling, L. M. Koch, A. Arm, P. Afanasyev, M. Linsenmeier, C. Eichmann, J. Zhou, Y. Cao, D. M. Pfizenmaier, S. Kroschwald, T. Wiegand, R. Cadalbert, D. Boehringer, R. Mezzenga, , M. Peter

This study identifies a conserved mechanism by which pH-sensing regions regulate reversible amyloid formation in pyruvate kinase across yeast and human cells.

bioRxiv · Mar 21, 2022 · PreprintCell Biology

SF3B1 promotes tumor malignancy through splicing-independent co-activation of HIF1α

P. Simmler, C. Cortijo, L. M. Koch, P. Galliker, M. Schaefer, S. Angori, H. A. Bolck, C. Mueller, A. Vukolic, P. Mirtschink, Y. Christinat, N. R. Davidson, K.-V. Lehmann, G. Pellegrini, C. Pauli, , G. Schwank

This study shows SF3B1 promotes tumor malignancy by co-activating HIF1α through a splicing-independent mechanism, enhancing hypoxia response element binding and target gene expression.

bioRxiv · Nov 10, 2020Cell Biology

Coincidence detection of mitogenic signals via cytosolic pH regulates Cyclin D1 expression

L. M. Koch, E. Birkeland, S. Battaglioni, X. Helle, M. Meerang, S. Hiltbrunner, A. Ibanez, M. Peter, A. Curioni, I. Opitz, R. Dechant

The paper shows that elevated cytosolic pH regulates Cyclin D1 expression through E2F-dependent transcription and CREB1-p300/CBP interaction, linking pH changes to cell proliferation and cancer progression.

bioRxiv · Jul 15, 2020Cell Biology