Author

S. Hiltbrunner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

I. Opitz· 2 shared M. van den Broek· 2 shared A. Curioni· 1 shared A. Curioni-Fontecedro· 1 shared A. Ibanez· 1 shared A. Soltermann· 1 shared B. Becher· 1 shared B. Bodenmiller· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

I. Opitz

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Acquired resistance to anti-PD1 therapy in patients with NSCLC reveals changes in T cell phenotypes and MET amplification

S. Hiltbrunner, L. Cords, S. Kasser, S. N. Freiberger, S. Kreutzer, N. C. Toussaint, L. Grob, I. Opitz, M. Messerli, M. Zoche, A. Soltermann, M. Rechsteiner, M. van den Broek, B. Bodenmiller, A. Curioni-Fontecedro

This study identifies two patterns of acquired resistance to anti-PD1 therapy in NSCLC patients, including reduced T cell infiltration and MET amplification.

bioRxiv · Apr 8, 2022 · PreprintCancer Biology

Coincidence detection of mitogenic signals via cytosolic pH regulates Cyclin D1 expression

L. M. Koch, E. Birkeland, S. Battaglioni, X. Helle, M. Meerang, S. Hiltbrunner, A. Ibanez, M. Peter, A. Curioni, I. Opitz, R. Dechant

The paper shows that elevated cytosolic pH regulates Cyclin D1 expression through E2F-dependent transcription and CREB1-p300/CBP interaction, linking pH changes to cell proliferation and cancer progression.

bioRxiv · Jul 15, 2020Cell Biology

CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer

P. Tallon de Lara, H. Castanon, M. Vermeer, N. Nunez, K. Silina, B. Sobottka, J. Urdinez, V. Cecconi, F. Movahedian Attar, S. Hiltbrunner, I. Glarner, H. Moch, S. Tugues, B. Becher, M. van den Broek

This study identifies CD39+PD-1+CD8+ T cells as critical for metastatic dormancy in breast cancer, showing their role in suppressing tumor growth and their potential as a biomarker and immunotherapy target.

bioRxiv · Jun 2, 2020Cancer Biology