Programmable in vivo CRISPR activation elucidates the oncogenic and immunosuppressive role of MYC in lung adenocarcinoma
F. I. Thege, D. N. Rupani, B. B. Bharati, S. L. Manning, A. Maitra, A. D. Rhim, S. M. Woermann
This study uses CRISPR activation to show MYC promotes lung cancer growth and creates an immunosuppressive tumor environment, suggesting combined MYC/immune therapies could benefit patients.
bioRxiv · Dec 9, 2021 · PreprintCancer Biology