Author

F. I. Thege

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:spatial transcriptomics· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

A. Maitra· 4 shared J. Min· 3 shared K. I. Rajapakshe· 3 shared M. Sans· 3 shared Y. Makino· 3 shared C. M. Schmidt· 2 shared M. P. Kim· 2 shared M. W. Hurd· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

A. Maitra

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Author profile →

4 papers

Recent·Most cited

Metabolic Reprogramming by Mutant GNAS Creates an Actionable Dependency in Intraductal Papillary Mucinous Neoplasms of the Pancreas

Y. Makino, K. I. Rajapakshe, B. C. Selvanesan, T. Okumura, K. Date, P. Dutta, L. Abou-Elkacem, A. Sagara, J. Min, M. Sans, N. Yee, M. J. Siemann, J. Enriquez, P. Smith, P. Bhattacharya, , F. I. Thege

This study shows that mutant GNAS drives a gastric metaplasia gene signature and glycolytic dependency in IPMNs, offering a therapeutic target.

Gut · Sep 13, 2024Peer-reviewedCancer Biology

Integrated spatial transcriptomics and lipidomics of precursor lesions of pancreatic cancer identifies enrichment of long chain sulfatide biosynthesis as an early metabolic alteration

M. Sans, Y. Chen, F. I. Thege, R. Dou, J. Min, M. Yip-Schneider, J. Zhang, R. Wu, E. Irajizad, Y. Makino, K. I. Rajapakshe, M. W. Hurd, R. A. Leon, J. Vykoukal, J. B. Dennison, , J. F. Fahrmann

bioRxiv · Aug 14, 2023 · PreprintCancer Biology

Spatial Transcriptomics of Intraductal Papillary Mucinous Neoplasms of The Pancreas Identifies NKX6-2 as a Driver of Gastric Differentiation and Indolent Biological Potential

M. Sans, Y. Makino, J. Min, K. I. Rajapakshe, M. Yip-Schneider, C. M. Schmidt, M. W. Hurd, J. K. Burks, J. A. Gomez, F. I. Thege, J. Fahrmann, R. A. Wolff, M. P. Kim, P. A. Guerrero, A. Maitra

This study identifies NKX6-2 as a driver of gastric differentiation in IPMNs, linking its expression to indolent biological potential and progression.

Cancer Discovery · Jun 7, 2023Peer-reviewedCancer Biology

Programmable in vivo CRISPR activation elucidates the oncogenic and immunosuppressive role of MYC in lung adenocarcinoma

F. I. Thege, D. N. Rupani, B. B. Bharati, S. L. Manning, A. Maitra, A. D. Rhim, S. M. Woermann

This study uses CRISPR activation to show MYC promotes lung cancer growth and creates an immunosuppressive tumor environment, suggesting combined MYC/immune therapies could benefit patients.

bioRxiv · Dec 9, 2021 · PreprintCancer Biology