An unbiased screen identified the Hsp70-BAG3 complex as a regulator of myosin binding protein C3 stability.
A. D. Thompson, M. J. Wagner, J. Rodriguez, A. Malhotra, S. Vander Roest, U. Lilienthal, H. Shao, J. Yob, B. L. Prosser, A. S. Helms, J. E. Gestwicki, D. E. Ginsburg, S. M. Day
A high-throughput compound screen identified JG98 and parthenolide as reducing MyBP-C levels, revealing the Hsp70-BAG3 complex as a regulator of MyBP-C stability in HCM.
bioRxiv · Oct 8, 2022Cell Biology