Author

A. S. Helms

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:imaging· 1

Frequent Co-Authors

A. P. Liu· 2 shared S. Friedline· 2 shared S. J. DePalma· 2 shared Y.-C. Tsan· 2 shared A. Capilnasiu· 1 shared A. Chowdhury· 1 shared A. D. Thompson· 1 shared A. E. Stis· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

A. P. Liu

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Author profile →

4 papers

Recent·Most cited

Matrix architecture and mechanics regulate myofibril organization, costamere assembly, and contractility of engineered myocardial microtissues

S. J. DePalma, J. Jillberto, A. E. Stis, D. D. Huang, J. Lo, C. D. Davidson, A. Chowdhury, M. E. Jewett, H. Kobeissi, C. S. Chen, E. Lejeune, A. S. Helms, D. A. Nordsletten, B. Baker

This study investigates how matrix stiffness and alignment affect the structure and contractility of engineered myocardial tissues made from iPSC-derived cardiomyocytes.

bioRxiv · Oct 20, 2023Bioengineering

An unbiased screen identified the Hsp70-BAG3 complex as a regulator of myosin binding protein C3 stability.

A. D. Thompson, M. J. Wagner, J. Rodriguez, A. Malhotra, S. Vander Roest, U. Lilienthal, H. Shao, J. Yob, B. L. Prosser, A. S. Helms, J. E. Gestwicki, D. E. Ginsburg, S. M. Day

A high-throughput compound screen identified JG98 and parthenolide as reducing MyBP-C levels, revealing the Hsp70-BAG3 complex as a regulator of MyBP-C stability in HCM.

bioRxiv · Oct 8, 2022Cell Biology

Biomechanics and Myofibrillar Alignment Enhance Contractile Development and Reproducibility in Stem Cell Derived Cardiac Muscle

Y.-C. Tsan, Y.-T. Zhao, S. J. DePalma, A. Capilnasiu, Y.-W. Wu, B. Elder, I. Panse, S. Friedline, T. S. O'Leary, N. Wubshet, K. K. Y. Ho, M. J. Previs, D. Nordsletten, B. M. Baker, L. L. Isom, , A. S. Helms

This study develops a 2D platform to enhance contractile development and reproducibility in stem cell-derived cardiac muscle by controlling biomechanics and myofibrillar alignment.

bioRxiv · May 23, 2021 · PreprintCell Biology

Myofibrillar Structural Variability Underlies Contractile Function in Stem Cell-Derived Cardiomyocytes

K. Ufford, S. Friedline, Z. Tong, V. T. Tang, A. S. Dobbs, Y.-C. Tsan, S. L. Bielas, A. P. Liu, A. S. Helms

This study shows myofibrillar structure variability in iPSC-derived cardiomyocytes affects contractile function and should be considered in disease modeling and drug testing.

bioRxiv · Oct 13, 2020Cell Biology